Adverse Reactions

Generic manufacturers and consumer budgets are the big winners in the ongoing voluntary recall of millions of packages of pediatric liquid medications manufactured by McNeil Consumer Healthcare. (Source: Drug Topics - Top News)

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CONCLUSIONS: Triglyceride levels were lowered after initiating selective lipoprotein apheresis. More importantly, the patient did not experience any relapses of pancreatitis after the treatment was started. Hence this treatment is feasible in drug refractory hypertiglyceridemia, but the treatment concept needs to be tested in additional studies. PMID: 20818118 [PubMed - in process] (Source: JOP)

Allergan will pay $600 million for its marketing tactics while the F.D.A. decides on the drug’s use for migraines. (Source: NYT Health)

Allergan agreed to pay $600 million for Botox’s marketing getting ahead of approved uses. But the F.D.A. will soon decide on its effectiveness for migraines. (Source: NYT)

Expert Opinion on Drug Metabolism & Toxicology, Volume 0, Issue 0, Page 1-14, Early Online. (Source: Expert Opinion: Expert Opinion on Drug Metabolism and Toxicology: Table of Contents)

Expert Opinion on Drug Discovery, Volume 0, Issue 0, Page 1-7, Early Online. (Source: Expert Opinion: Expert Opinion on Drug Discovery: Table of Contents)

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An elevated liver function test for 1 patient appears to be related to gallstones, according to the chief medical officer of Idenix. Medscape Medical News (Source: Medscape Today Headlines)

New York State Agriculture Commissioner Patrick Hooker today alerted consumers that Midland Farms, located in Menands, New York, is voluntarily recalling certain milk products due to the potential of improper pasteurization. Proper pasteurization heats milk in order to effectively eliminate all pathogenic bacteria, such as Listeria and Salmonella. (Source: Food and Drug Administration)

It has emerged this week that UK experts recommended the withdrawal of the diabetes drug rosiglitazone from the British market in July, although this recommendation was not made public at the time. Heartwire (Source: Medscape Today Headlines)

With GP consortia on course to take over commissioning, a report seen by HSJ shows PCTs have been preparing the ground well by getting to grips with the fundamentals of local priority setting. Dave West explains (Source: HSJ)

Conclusions: Histamine may mediate the effects of food additives on ADHD symptoms, and variations in genes influencing the action of histamine may explain the inconsistency between previous studies. Genes influencing a range of neurotransmitter systems and their interplay with environmental factors, such as diet, need to be examined to understand genetic influences on ADHD symptoms. (Source: Am J Psychiatry)

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Conclusions: A highly heritable general liability accounts for the parent-child transmission of externalizing psychopathology from parents to their preadolescent offspring. This general liability should be a focus of research for both etiology and intervention. (Source: Am J Psychiatry)

Digestion 2011;83:1–2 (DOI:10.1159/000315888) (Source: Digestion)

Generic manufacturers and consumer budgets are the big winners in the ongoing voluntary recall of millions of packages of pediatric liquid medications manufactured by McNeil Consumer Healthcare. (Source: Drug Topics - Pharmacy News)

Psychother Psychosom 2010;79:389–391 (DOI:10.1159/000320899) (Source: Psychotherapy and Psychosomatics)

The FDA has warned the manufacturers of two popular green tea beverages that some of their nutritional claims are unauthorized and in violation of the Federal Food, Drug, and Cosmetic Act. (Source: WebMD Health)

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Working as a college professor for the first dozen years of my post-graduate school life, I was always around people. Teaching a full load of courses to college students every semester, I used to say, "I talk for a living." Then I would come home to my husband and children and more talking. Life was full of what I now call "Face-to-Face" or F2F communication.Back in those days, I remember one fine afternoon, sitting on the quad with a circle of honors students. We were discussing Csikszentmihalyi's Finding Flow: The Psychology of Engagement with Everyday Life. The author made the point that people generally dislike or fear being alone and that this condition stemmed from a time when being alone meant greater vulnerability to harm. An animal that strays from the pack puts herself at greater...

(Source: NIGMS - Results)

Histopathologic examination reveals that most human tumors are associated with diverse immune cell infiltrates, but the roles of host reactions in disease pathogenesis and prognosis remain to be fully clarified. Recent investigations in genetically engineered murine tumor models have uncovered dual functions for immune responses during cancer development and progression. Alterations in tumor cell gene expression profiles and coding sequences may trigger the activation of cytotoxic lymphocytes, which act to restrain tumor growth. In contrast, persistent inflammatory reactions, which may be driven by infection, environmental toxins, or impaired immune regulation, create a microenvironment that fosters tumor cell growth, survival, invasion, and dissemination. The dynamic interplay of these co...

Multivitamins and multiminerals are widely used in the United States, but their efficacy and, perhaps more importantly, the potential for harm in individuals who have cancer have received relatively little study. Beyond their general effects on health, the use of vitamins and minerals by patients with cancer has unique implications because of their potential direct effects on existing cancers, effects on factors that may influence carcinogenesis, such as immunity, and interactions with treatment. Some evidence suggests that vitamin D at higher than standard doses may improve cancer-specific and overall survival for several cancer sites. Besides vitamin D, there is little evidence that nutritional supplements lower the risk of recurrence or improve survival from cancer, although some benefi...